Only PROMETRIUM® is bio-identical to progesterone.*

Chemical structures of endogenous progesterone and PROMETRIUM^®

• PROMETRIUM® is micronized progesterone, synthesized from a
  plant source.[2]
• PROMETRIUM® is chemically identical to progesterone of human
  ovarian origin.*[2]

*Clinical significance is unknown.

PROMETRIUM® (progesterone, USP) Capsules are indicated for use in the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women who are receiving conjugated estrogens tablets, as well as for treatment of secondary amenorrhea.[2]

PROMETRIUM® is contraindicated for patients with any of the following conditions: known hypersensitivity to any of its ingredients; undiagnosed abnormal genital bleeding; known, suspected, or history of cancer of the breast; active deep vein thrombosis, pulmonary embolism, or history of these conditions; active or recent (within the past year) arterial thromboembolic disease (e.g., stroke, myocardial infarction); liver dysfunction or disease; or known or suspected pregnancy.[2]

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References:
1. AHFS 2000 Drug Information. Bethesda, Md: American Society of Health-System Pharmacists, Inc.; 2000. 2. PROMETRIUM® [package insert]. Marietta, Ga: Solvay Pharmaceuticals, Inc.; 2004.